Triiodothyronine Regulation of Multiple Rat Hepatic Genes: Requirement for Ongoing Protein Synthesis
نویسندگان
چکیده
منابع مشابه
The regulation of hepatic protein synthesis during fasting in the rat.
We have studied translational control in the model of 48 h of fasting in the rat. Our initial observations showed a paradoxical increase in ribosomal protein S6 (rpS6) phosphorylation and a decrease in eukaryotic initiation factor 2alpha (eIF2alpha) phosphorylation. These effects, which would favor an increase in protein synthesis, could be attributed to increased circulating concentrations of ...
متن کاملRequirement for protein synthesis at developing synapses.
Activity and protein synthesis act cooperatively to generate persistent changes in synaptic responses. This forms the basis for enduring memory in adults. Activity also shapes neural circuits developmentally, but whether protein synthesis plays a congruent function in this process is poorly understood. Here, we show that brief periods of global or local protein synthesis inhibition decrease the...
متن کاملRat Hepatic Cytochrome P450 Genes
Cytochromes P450 (P450) collectively refer to a superfamily of heme-containing enzymes that use 02 and electrons from NADPH to insert a single atom of oxygen into any one of a large number of substrates. Two general classes of P450s exist; a relatively limited number of P450 forms, expressed in specialized tissues that are associated with pathways of steroidogenesis and a large number of forms ...
متن کاملRegulation of specific rat liver messenger ribonucleic acids by triiodothyronine.
A plasmid cDNA library was constructed using poly(A+) RNA isolated from the livers of rats treated with 3,5,3'-triiodothyronine (T3) and fed a high carbohydrate diet. This library was screened by differential colony hybridization with [32P]cDNA probes made from hypothyroid and hyperthyroid rat liver poly(A+) RNA to obtain clones representing T3-inducible mRNAs. Using plasmid cDNAs to 4 differen...
متن کاملRequirement of Protein Synthesis for Bacteriophage stX 174 Superinfection Exclusion
Within 5 to 10 min at 37 C, bacteria infected by bacteriophage OX174 acquire the ability to exclude superinfecting OX particles from reproducing themselves. The superinfecting phage are blocked at a stage prior to synthesis of the parental replicative form molecule; the superinfecting deoxyribonucleic acid remains as intact (infective) single strands. Establishment of superinfection exclusion a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Endocrinology
سال: 1987
ISSN: 0888-8809,1944-9917
DOI: 10.1210/mend-1-6-397